Clinical-epidemiological characterization of pulmonary tuberculosis-VIH co-infection patients at José Rodríguez hospital 2015-2016

Abstract

Context: Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis; it is the first opportunistic disease in HIV-positive patients. Objective: To clinically and epidemiologically characterize patients presenting HIV-Pulmonary tuberculosis co-infection, at José Rodríguez Maridueña Hospital, between January 2015 and December 2016. Methodology: This is a descriptive, cross-sectional, and retrospective study based on the analysis of the clinical records of diagnosed pulmonary tuberculosis and HIV patients at José Rodríguez Maridueña Hospital, between January 2015 and December 2016. Results: The coinfection rate was 44.9% (IC95% 37.12-52.69). The pooled analysis of the variables revealed that these people were older than 37 years (adjusted OR 3.45; IC95% 1.37-8.68), they had primary education (adjusted OR 2.67; 95% CI 1.20-6.28) were diagnosed by other methods (adjusted OR 3.23; 95% CI 1.35-7.76). Their viral load was less than 175318 copies RNA/mL (adjusted OR 4.73; 95% CI 1.77-12.6), CD4 less than 140 (adjusted OR 2.94; 95% CI 1.18-7.29), and were not taking HAART (OR 3.00; 95% CI 2.36-3.80).  Conclusions: The risk profile in this co-infection is to be 37 years or older, with primary education; to be diagnosed by methods other than bacilloscopy, to have a viral load smaller than 175318 copies RNA/mL, with a TCD4+ lymphocyte count less than 140 cells/mm3, and not to be taking HAART (100%).